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Honey bees display a fascinating division of labor among foragers. While some bees solely collect pollen, others only collect nectar. It is assumed that individual differences in sensory response thresholds are at the basis of division of labor. Biogenic amines and their receptors are important candidates for regulating division of labor, because they can modulate sensory response thresholds. We here investigate the role of the honey bee tyramine receptor AmTYR1 in regulating division of foraging labor. We report differential splicing of the Amtyr1 gene and show differential gene expression of one isoform in the suboesophageal ganglion of pollen and nectar foragers. This ganglion mediates gustatory inputs. These findings imply a role for the honey bee tyramine receptor in regulating division of foraging labor, possibly through the suboesophageal ganglion.